Cardiac Contractility Modulation (CCM) is a therapy primarily indicated for patient's with heart failure, especially those who remain symptomatic despite optimal medical therapy. It involves the use of specialised devices that deliver electrical impulses to the heart during the absolute refractory period. These impulses aim to improve the heart's contractile function without causing muscle contractions, thereby enhancing cardiac output and overall performance. Clinical trials have also demonstrated its potential to enhance exercise capacity, reduce heart failure symptoms, and improve patient's quality of life.
Suitable candidates are typically individuals with heart failure who have exhausted conventional treatment options. Candidates should have a reduced left ventricular ejection fraction (LVEF) and show signs of heart failure despite adherence to guideline-directed medical therapy (GDMT). Additionally, factors like age, comorbidities, and individual preferences should be considered when determining eligibility.
The implantation of CCM devices is a specialised procedure conducted by experienced cardiac electrophysiologists.
During the procedure, a small incision is made near the collarbone, and a pocket is created beneath the skin to hold the CCM device. Leads, which are thin, flexible wires with electrodes at their tips, are carefully threaded through a vein into the heart. The exact number of leads and their placement locations may vary depending on the patient’s individual needs. Typically, two leads are placed in the right ventricle, but the precise positioning may be adjusted based on the patient’s condition.
Once implanted, the device’s parameters are adjusted based on the patient’s specific cardiac rhythms and requirements. This customisation ensures that the electrical impulses synchronise effectively with the heart’s natural contractions.
Regular follow-up appointments are essential to monitor the device’s performance, adjust settings if necessary, and ensure its long-term effectiveness. Proper patient education regarding device management and the recognition of any potential issues is vital.
Several key considerations and precautions are associated with CCM therapy. These include:
Ensuring that CCM devices are compatible with other implanted devices or treatments the patient may be receiving.
Patient's should be informed about potential side effects, which may include discomfort at the implant site, skin irritation, or muscle twitching during stimulation.
Regular monitoring of patient's response to CCM therapy is essential to assess its effectiveness and make any necessary adjustments.
Provide patient's with guidance on recognising and responding to device alerts or complications, and advise them to carry an identification card indicating the presence of their CCM device in case of emergencies.
Advancements in CCM technology will likely lead to more personalised and effective therapies for heart failure. Innovations may include improved device miniaturisation, enhanced patient monitoring, and optimised stimulation algorithms, offering better outcomes and quality of life.
Atrius pioneers cutting-edge CCM therapies with a multidisciplinary team of experts. Our patient-centric approach ensures tailored treatment plans, fostering improved heart function and enhanced overall well-being. We ensure patient’s get access to the latest advancements and comprehensive support for heart failure management.